UKB Klinik und Poliklinik für Neurologie
Universitätsklinikum Bonn
Sigmund-Freud-Str. 25
D-53105 Bonn
Tel: 0228-287-15750
 
Uni-Bonn
vorherige Seite | nächste Seite | Telefonlisten | Stationäre Aufnahme | Suchen | Impressum

Genebank Parkinson´s disease (GEPARD)

Parkinson´s disease (PD) is only rarely inherited following Mendelian laws. Nevertheless, family and twin studies suggest that genetic factors contribute to the development of sporadic PD. Genetic factors are particularly strong in patients with an disease onset before the age of 50 years. Whereas mutations of single genes determine the disease in classical hereditary diseases, a larger number of genetic variations are involved in the aetiology of sporadic PD. It is assumed that the combination of various genetic polymorphisms each of which alone is not pathogenic increases the likelihood to develop PD. Genetic polymorphisms may also contribute to the phenotypical variation observed in PD. To understand the complex genetic aetiology studies of large numbers of patients, family members and healthy control persons are required. To facilitate such studies the German PD Gene Bank (Genbank Parkinson´sche Krankheit Deutschland, GEPARD) was established in Bonn as part of the BMBF-sponsored PD competence net (Kompetenznetz Parkinson, KNP). GEPARD collects and stores DNA samples of PD patients, their relatives and controls. Currently, GEPARD contains approximately 3000 DNA samples.


Key Publications

1: Wüllner U, Standop J, Kaut O, Coenen V, Kalenka A, Wappler F. [Parkinson's disease]. Perioperative management and anesthesia]. Anaesthesist. 2012 Feb;61(2):97-105. German. PubMed PMID: 22354395.

2: Kaut O, Schmitt I, Wüllner U. Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1. Neurogenetics. 2012 Feb;13(1):87-91. Epub 2012 Jan 12. PubMed PMID: 22238121.

3: Balzer-Geldsetzer M, Costa AS, Kronenbürger M, Schulz JB, Röske S, Spottke A, Wüllner U, Klockgether T, Storch A, Schneider C, Riedel O, Wittchen HU, Seifried C, Hilker R, Schmidt N, Witt K, Deuschl G, Mollenhauer B, Trenkwalder C, Liepelt-Scarfone I, Gräber-Sultan S, Berg D, Gasser T, Kalbe E, Bodden M, Oertel WH, Dodel R. Parkinson's disease and dementia: a longitudinal study (DEMPARK). Neuroepidemiology. 2011;37(3-4):168-76. Epub 2011 Nov 4. PubMed PMID: 22067139.

4: Kaut O, Allert N, Coch C, Paus S, Grzeska A, Minnerop M, Wüllner U. Stochastic resonance therapy in Parkinson's disease. NeuroRehabilitation. 2011;28(4):353-8. PubMed PMID: 21725168.

5: Schwarz J, Odin P, Buhmann C, Csoti I, Jost W, Wüllner U, Storch A. Depression in Parkinson's disease. J Neurol. 2011 May;258(Suppl 2):S336-8. Review. PubMed PMID: 21560065.

6: Wüllner U, Kassubek J, Odin P, Schwarz M, Naumann M, Häck HJ, Boroojerdi B, Reichmann H; NEUPOS Study Group. Transdermal rotigotine for the perioperative management of Parkinson's disease. J Neural Transm. 2010 Jul;117(7):855-9. Epub 2010 Jun 10. PubMed PMID: 20535621; PubMed Central PMCID: PMC2895903.

7: Jowaed A, Schmitt I, Kaut O, Wüllner U. Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J Neurosci. 2010 May 5;30(18):6355-9. PubMed PMID: 20445061.

8: Paus S, Gadow F, Kaut O, Knapp M, Klein C, Klockgether T, Wüllner U. Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism. Parkinsonism Relat Disord. 2010 Jul;16(6):381-3. PubMed PMID: 20434388.

9: Kassubek J, Büttner T, Reichmann H, Riederer P, Schulz JB, Wüllner U, Csoti I. [On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease]. Fortschr Neurol Psychiatr. 2010 Mar;78 Suppl 1:S34-6. Epub 2010 Mar 1. Review. German. PubMed PMID: 20195940.

10: Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wüllner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Del Sorbo F, Schneider S, Bhatia KP, Gasser T. SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol. 2009 May;65(5):610-4. Erratum in: Ann Neurol. 2010 Feb;67(2):277. Del Sorbo, Francesca [added]; Schneider, Susanne [added]; Bhatia, Kailash P [added]. PubMed PMID: 19475667.

11: Paus S, Gadow F, Knapp M, Klein C, Klockgether T, Wüllner U. Motor complications in patients form the German Competence Network on Parkinson's disease and the DRD3 Ser9Gly polymorphism. Mov Disord. 2009 May 15;24(7):1080-4. PubMed PMID: 19353703.

12: Wüllner U, Schmitt I, Kammal M, Kretzschmar HA, Neumann M. Definite multiple system atrophy in a German family. J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):449-50. PubMed PMID: 19289484.

13: Biskup S, Gerlach M, Kupsch A, Reichmann H, Riederer P, Vieregge P, Wüllner U, Gasser T. Genes associated with Parkinson syndrome. J Neurol. 2008 Sep;255 Suppl 5:8-17. Review. PubMed PMID: 18787878.

14: Müller MC, Jüptner U, Wüllner U, Wirz S, Türler A, Wirtz DC, Hirner A, Standop J. [Parkinson's disease influences the perioperative risk profile in trauma patients]. Z Orthop Unfall. 2008 Mar-Apr;146(2):227-30. German. PubMed PMID: 18404587.

15: Paus S, Grünewald A, Klein C, Knapp M, Zimprich A, Janetzky B, Möller JC, Klockgether T, Wüllner U. The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease. Mov Disord. 2008 Mar 15;23(4):599-602. PubMed PMID: 18175338.

16: Wüllner U, Schmitz-Hübsch T, Antony G, Fimmers R, Spottke A, Oertel WH, Deuschl G, Klockgether T, Eggert K. KNP e.V. Autonomic dysfunction in 3414 Parkinson's disease patients enrolled in the German Network on Parkinson's disease (KNP e.V.): the effect of ageing. Eur J Neurol. 2007 Dec;14(12):1405-8. Epub 2007 Oct 17. PubMed PMID: 17941852.

17: Fuchs J, Mueller JC, Lichtner P, Schulte C, Munz M, Berg D, Wüllner U, Illig T, Sharma M, Gasser T. The transcription factor PITX3 is associated with sporadic Parkinson's disease. Neurobiol Aging. 2009 May;30(5):731-8. Epub 2007 Oct 1. PubMed PMID: 17905480.

18: Popp J, Schaper K, Kölsch H, Cvetanovska G, Rommel F, Klingmüller D, Dodel R, Wüllner U, Jessen F. CSF cortisol in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2009 Mar;30(3):498-500. Epub 2007 Aug 22. PubMed PMID: 17716786.

19: Paus S, Schmitz-Hübsch T, Wüllner U, Vogel A, Klockgether T, Abele M. Bright light therapy in Parkinson's disease: a pilot study. Mov Disord. 2007 Jul 30;22(10):1495-8. PubMed PMID: 17516492.

20: Wüllner U, Schmitz-Hübsch T, Abele M, Antony G, Bauer P, Eggert K. Features of probable multiple system atrophy patients identified among 4770 patients with parkinsonism enrolled in the multicentre registry of the German Competence Network on Parkinson's disease. J Neural Transm. 2007 Sep;114(9):1161-5. Epub 2007 May 18. PubMed PMID: 17510732.

21: Eggert K, Wüllner U, Antony G, Gasser T, Janetzky B, Klein C, Schöls L, Oertel W. Data protection in biomaterial banks for Parkinson's disease research: the model of GEPARD (Gene Bank Parkinson's Disease Germany). Mov Disord. 2007 Apr 15;22(5):611-8. PubMed PMID: 17230444.



vorherige Seite | nächste Seite
Home
Suchen
Anfahrt
Patientenservice
Telefonnummern
und E-Mail-Adressen
Neuroonkologie
Schlafmedizin
Lehre
Forschung
Glas Experimental and Translational Neurooncology
Heneka Neuroinflammation
Herrlinger Clinical Neurooncology
Kaut / Wüllner
EPIGENETICS in Parkinson’s disease
Klockgether Ataxias
Kornblum / Reimann
Muscle Diseases
Minnerop / Wüllner / Klockgether
Neuroimaging
Müller Neuroimmunology
Petzold
Walter Neurodegeneration
Wüllner
Genebank Parkinson's disease (GEPARD)
Background & Research
Staff
Publications
Fundings
Past & Present Projects
Curriculum Vitae
Klinische Studien
Arbeitsgruppe Neurobiologie
(Leiter: Prof. Dr. med. U. Wüllner)
Publications
Links
Impressum
tuevlogo.png, 13kB